0
ISBN
9781118916933
Genre
Algemeen
Verschenen
15-05-2017
Bindwijze
Ebook EPUB
Taal
Engels
Uitgever
Wiley
Auteur(s)
Ayman F. El-Kattan ; Mike S. Lee
Oral Bioavailability Assessment
Basics and Strategies for Drug Discovery and Development
Reeks: Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
Ayman F. El-Kattan ; Mike S. Lee
In winkelmandje
Leesfragment
€156,99
Specifically
geared
to
personnel
in
the
pharmaceutical
and
biotechnology
industries,
this
book
describes
the
basics
and
challenges
of
oral
bioavailability
–
one
of
the
most
significant
hurdles
in
drug
discovery
and
development.•
Describes
approaches
to
assess
pharmacokinetics
and
how
drug
efflux
and
uptake
transporters
impact
oral
bioavailability •
Helps
readers
reduce
the
failure
rate
of
drug
candidates
when
transitioning
from
the
bench
to
the
clinic
during
development •
Explains
how
preclinical
animal
models
–
used
in
preclinical
testing
–
and
in
vitro
tools
translate
to
humans,
which
is
an
underappreciated
and
complicated
area
of
drug
development •
Includes
chapters
about
pharmacokinetic
modelling,
the
Biopharmaceutics
Drug
Disposition
Classification
System
(BDDCS),
and
the
Extended
Clearance
Classification
System
(ECCS) •
Has
tutorials
for
applying
strategies
to
medicinal
chemistry
practices
of
drug discovery/development
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