The Omega Device follows Tattoist Maggie Doherty and Detective Russell Williams as they seek out why they have become targets to Omega: an organization seemingly hell-bent on chasing them around the world in hopes of killing them. What the pair learn along the way is a series of daunting realities that upends the world they thought they knew. What's more, Omega falsely believes them in possession of information related to an ancient weapon meant to exterminate Humanity. The realization soon dawns on them that it may not be they alone at risk if they fail to uncover the truth, and summarily, destroy the weapon. As they make their way through Ohio, Nevada, Nepal, and Tibet, Omega's military strike-force pursues.
But when Maggie and Russell find information only Omega can decipher, they are forced to team up with those hunting them. Maggie learns black-mail and intimidation are all that keeps Omega's people loyal, and offers a way out. The group must decode the information and locate the weapon before Omega learns of their betrayal. But can they locate and destroy the weapon in time to save Humanity, or indeed, themselves?